New default settings
Gain reduction by default on all tracks

Mouse Scroll - scroll vertically (default was zoom)

New Tracks are colored by default (and children of folders)
via cmd / ctrl + t for new tracks (double click create grey track)
and cmd / ctrl + g for folders

Toggle folders with one key - H

60 Hz Meters
(was - 30Hz)

No seek
You can click while playback, and playhead will not jump immediately (just like in every other DAW).

One FX chain window per selected track

Disabled auto check for updates

Command line updates (advanced)
It's easier to handle updates with winget - Windows, or brew - macOS with admin terminal.
To install REAPER on Windows:
winget install Cockos.REAPER
to update:
winget upgrade Cockos.REAPER
to install on macOS:
brew install --cask reaper
to update:
brew upgrade --cask reaper